Johnny Depp

Rango / Lars (voice)

Isla Fisher

Beans (voice)

Ned Beatty

Mayor (voice)

Bill Nighy

Rattlesnake Jake (voice)

Abigail Breslin

Priscilla (voice)

Alfred Molina

Roadkill (voice)

Stephen Root

Doc / Merrimack / Mr. Snuggles (voice)

Harry Dean Stanton

Balthazar (voice)

Timothy Olyphant

Spirit of the West (voice)

Ray Winstone

Bad Bill (voice)

Ian Abercrombie

Ambrose (voice)

Gil Birmingham

Wounded Bird (voice)