Bill Murray

Garfield (voice)

Breckin Meyer

Jon

Jennifer Love Hewitt

Liz

Stephen Tobolowsky

Happy Chapman

Evan Arnold

Wendell

Mark Christopher Lawrence

Christopher Mello

Jimmy Kimmel

Spanky (voice)

Debra Messing

Arlene (voice)

Nick Cannon

Louis (voice)

Alan Cumming

Persnikitty (voice)

Brad Garrett

Luca (voice)

David Eigenberg

Nermal (voice)