Jeff Goldblum

Professor Brody

Elizabeth Perkins

Mrs. Brody

Alexander Pollock

Scotty Brody

Miriam Margolyes

Sophie the Castle Maid

Tobey Maguire

Lou the Beagle (voice)

Alec Baldwin

Butch (voice)

Sean Hayes

Mr. Tinkles (voice)

Susan Sarandon

Ivy (voice)

Joe Pantoliano

Peek (voice)

Michael Clarke Duncan

Sam (voice)

Jon Lovitz

Calico (voice)

Charlton Heston

The Mastiff (voice)